Analytical Techniques , Methods & Analytical Science Books

Natural Products Isolation Methods and Protocols

 

3rd ed. 2012, XII, 552p. 147 illus., 4 illus. in color.

Hardcover.

 

• Reflects the significant progress made in natural materials isolation and extraction
• Features detailed methods and protocols tested and proven in labs around the world
• Includes expert tips and key implementation advice to ensure successful results

With significant developments in the areas of chromatography and spectroscopy as well as the unique inherent chemical diversity of natural products, vital in drug research, natural products research has gained new momentum.  Fully updating and adding to the previous two editions, Natural Products Isolation, Third Edition documents the latest methods and technologies for natural products isolation with a combination of all new chapters and revised and expanded classic methods.  Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and up-to-date, Natural Products Isolation, Third Edition provides the substantial background information needed by budding natural product researchers as well offering an invaluable reference guide to available methodologies and techniques for the more experienced researchers.

Content Level » Professional/practitioner

 

Contents :

Dedication
Preface
Contributors

1 An Introduction to Natural Products Isolation

2 Initial and Bulk Extraction of Natural Products Isolation

3 Supercritical Fluid Extraction in Natural Products Analyses

4 Accelerated Solvent Extraction for Natural Products Isolation

5 Microwave-Assisted Extraction in Natural Products Isolation.

6 An Introduction to Planar Chromatography and Its Application
to Natural Products Isolation

7 Isolation of Natural Products by Low-Pressure
Column Chromatography

8 Isolation of Natural Products by Ion-Exchange Method

9 Separation of Natural Products by Countercurrent Chromatography.

10 Isolation of Natural Products by Preparative High Performance
Liquid Chromatography (Prep-HPLC)
r

11 Isolation of Natural Products by Preparative Gas Chromatography

12 Hyphenated Techniques and Their Applications in Natural
Products Analysi

13 Extraction of Plant Secondary Metabolites

14 Isolation of Marine Natural Product

15 Isolation of Microbial Natural Products.

16 Extraction and Isolation of Saponins

17 Extraction and Isolation of Phenolic Compound

18 Scaling-Up of Natural Products Isolation

19 Follow-Up of Natural Products Isolation.

20 Natural Products Isolation in Modern Drug Discovery Programs

Index

LC/MS A Practical User's Guide by Marvin McMaster provides an in-depth information on how to use and maintain the LC/MS system. With an easy to use and hands on reference, the book enables one to understand the subject in the most convenient manner.

Features:

• Premium quality
• Exceptional design
• Universal solutions

Detailing:

• A practical guide book
• Comprises of 184 pages in total
• The Power Point slide-set on CD-ROM (that comes with the book) provides vital teaching tools for instructors and new equipment operators

Published in the year 2010, the Handbook of Modern Pharmaceutical Analysis, 10 the handbook provides case studies and methodologies that have been edited by Satinder Ahuja, and Stephen Scypinski for a better understanding and in-depth information. This handbook is perfect for organic chemists, pharmaceutical chemists, Method development chemists, medicinal chemists, analytical chemists, biochemists, and licensing authorities.

Features:

• Easy explanation
• Premium quality
• Highly demanded

 

TABLE OF CONTENTS:

• Overview (Satinder Ahuja)
• High Throughput Screening in Drug Discovery and Development (Ken Apple)
• Solid-State Analysis (Harry Brittain)
• Degradation Studies of Drug Candidates (Karen Alsante)
• Analytical Considerations for Genotoxic and Other Impurities (Scott Miller)
• Quality by Design (James Drennen)
• Preformulation Studies (tba)
• Process Analytical Technology (Christine Richardson)
• Solid Dosage-Form Analysis (Joe Etse)
• Parenteral Dosage Form Analysis (Greg Birrer)
• Analysis of Alternate Drug Delivery systems (Ron Smith)
• Method Development for Chiral Compounds (S. Ahuja)
• Method Development for Early Phase Drug Development (Kevin Bynum)
• Method Development for Late Phase Drug Development (Ilias Jimidar)
• Analysis of Biomolecules (Ilias Jimidar)
• Setting Up Specifications (Doug Raynie)
• Validation of Test Methods (Jonathan Crowther)
• Stability Evaluations (Jessica Cha)
• Transferring Analytical Methods (Stephen Scypinski)
• Pharmaceutical Analysis Documentation (H. Chokshi)
• Emerging Analytical Methodologies (Jim Lander)

Quality Assurance in Analytical Chemistry

Training and Teaching

Wenclawiak, Bernd W., Koch, Michael, Hadjicostas, Evsevios (Eds.)

2nd ed. 2010, XVIII, 331p.

 

 

• Get acquainted with this important topic quickly and easily
• Over 800 Powerpoint slides available for download
• Practically all-new chapters on measurement uncertainty, calibration and validation

This new edition of a successful textbook has been completely revised and enlarged. In particular the chapters on measurement uncertainty, calibration and validation are practically all new. The authors provide an in-depth but easy to understand coverage of quality assurance for chemical measurements. This includes both internal as well as external quality assurance, necessary statistics as well as total quality management. All this is presented with more than 800 commented slides, which are also provided as downloadable Extra Material. The book will serve as an advanced textbook for analytical chemistry students and professionals in industry and service labs and as a reference text and source of course materials for lecturers.

Content Level » Professional/practitioner

Keywords » Analytical Chemistry - GLP - ISO Guide 99 - ISO/IEC 17025 - Laboratory - VIM - accreditation - certification - laboratory tests - measurement uncertainty - proficiency testing - quality assurance - quality assurance in analytical chemistry - reliability - validation

 

 

TABLE OF CONTENTS :

Glossary of Analytical Chemistry Terms (GAT).- Accreditation – ISO/IEC 17025.- ISO 9000 Quality Management System.- Accreditation or Certification for Laboratories?.- Good Laboratory Practice.- Total Quality Management and Cost of Quality.- Quality Manual.- Basic Statistics.- Calibration.- Metrology in Chemistry and Traceability of Analytical Measurement Results.- Validation of Analytical Methods – to be Fit for the Purpose.- Measurement Uncertainty.- Control Charts.- (Certified) Reference Materials.- Interlaboratory Tests.

Basic Gas Chromatography by Harold M. MC Nair and James M. Miller the book covers various topics such as Gas chromatography-mass spectrometry (GC-MS), Sampling methods, Multidimensional gas chromatography, Fast gas chromatography, Fast gas chromatography and many more.

Features:

• It is a Hardcover book
• Quality Bound
• Excellent layout
• Affordable costs

 

INTRODUCTION:

• A Brief History
• Definitions
• Overview: Advantages and Disadvantages
• Instrumentation
• References

INSTRUMENT OVERVIEW:

• Carrier Gas
• Flow Control and Measurement
• Sample Inlets and Sampling Devices
• Columns
• Temperature Zones
• Detectors
• Data Systems
• References

BASIC CONCEPTS AND TERMS:

• Definitions, Terms and Symbols
• The Rate Theory
• A Redefinition of H
• The Achievement of Separation
• References

Organic Structures from Spectra, 4th Edition by L.D. Field and J R Kalman, the Organic Structures from Spectra, 4^th Edition comprises of over 300 structural problems that deals with majority of the spectroscopic techniques in details. The problems are dealt in such a manner so that it helps in the student’s understanding of the subject matter. The book provides an in-depth theoretical knowledge.

Features:

• Quality Bound
• Excellent layout
• Affordable costs

Detailing:

• As with previous editions, this book combines basic theory, practical advice and sensible approaches to solving spectra problems.

Written by Lloyd R. Snyder, Joseph J. Kirkland and John W. Dolan is intended to meet the needs, demands of HPLC users. The book is written in such a way so that whether you are a novice or an expert Introduction to Modern Liquid Chromatography, Third Edition provides an up-to-date, extensive, and accessible survey of HPLC methods and applications available.

 

Features:

 

• Exceptional print
• Great design
• Error free
• Highly informative

Detailing:

• The basis of HPLC separation and the general effects of different experimental conditions
• Equipment and detection
• The column—the "heart" of the HPLC system
• Reversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques
• Computer simulation, qualitative and quantitative analysis, and method validation and quality control
• The separation of large molecules, including both biological and synthetic polymers
• Chiral separations, preparative separations, and sample preparation
• Systematic development of HPLC separations—new to this edition
• Troubleshooting tricks, techniques, and case studies for both equipment and chromatograms

Written by y Stephen Richards, and John Hollerton, Essential Practical NMR for Organic Chemistry informs the reader on the various factors of NMR spectroscopy and how they deal with problems of small organic molecule structural elucidation.

 

Features:

• Fine quality
• Excellent layout
• High demand

Detailing:

• Getting Started
• Preparing the Sample
• Spectrum Acquisition
• Processing
• Interpreting Your Spectrum
• Delving Deeper
• Further Elucidation Techniques – Part 1
• Further Elucidation Techniques – Part 2
• Carbon-13 NMR Spectroscopy
• Some of the Other Tools
• Some of the Other Nuclei
• Quantification
• Safety
• Software
• Problems

High Performance Liquid Chromatography In Phytochemical Analysis

Features:

• Describes the techniques and instrumentation of HPLC analysis, such as gradient elution and computer-assisted methods, HPLC/mass spectrometry, HPLC/nuclear magnetic resonance spectrometry, HPLC with photodiode array detection, HPLC chiral analysis, and much more
• Discusses how HPLC is used for analyzing herbal drugs and dietary supplements
• Explores the application of HPLC to primary and secondary plant metabolites, including carbohydrates, lipids, amino acids, peptides, proteins, shikimic acid derivatives, coumarins, flavonoids, lignans, isoprenoids, diterpenes, tripenes, polyterpenes, steroids, iridoids, amino acid derivatives, alkaloids, polyacetylenes, and quinoids
• Draws on the unparalleled expertise of an international team of contributors

Summary:

• The powerful, efficient technique of high performance liquid chromatography (HPLC) is essential to the standardization of plant-based drugs, identification of plant material, and creation of new herbal medicines. Filling the void in this critical area, High Performance Liquid Chromatography in Phytochemical Analysis is the first book to give a complete description of the techniques, materials, and instrumentation of column HPLC and its application to essentially all primary and secondary plant metabolites. Hailing from around the world and with vast expertise in HPLC phytochemical analysis, the contributors present a global, authoritative view of the field.
• The book looks at the role of HPLC in the analysis of herbal drugs, quality control of plant products in dietary supplements, and chemosystematics. It also covers the phytochemistry, pharmacology, and biological role of plant metabolites as well as various modes and techniques of HPLC analysis. The book then focuses on HPLC separation, identification, and quantification of particular classes of compounds in a variety of sample types, including plants, plant extracts, and plant-derived products.
• Along with its companion volume Thin Layer Chromatography in Phytochemistry, this comprehensive book presents the most important analytical approaches used in phytochemical analysis. It will help in solving problems connected with practical separations and the analyses of plant extract fractions of active metabolites.

PART I:

• Overview of the Field of Column High Performance Liquid Chromatography in Phytochemical Analysis and the Structure of the Book,
• Herbal Drugs and the Role of Chromatographic Methods in Their Analysis,
• Plant Products in Nutrition and Dietary Supplements: Quality Control,
• HPLC in Chemosystematics,
• Phytochemistry, Phytopharmacology, and the Biological Role of Plant Metabolites,
• Sample Preparation of Plant Material,

Hardcover641 pages

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Preface

List of Contributors

• Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases (Thomas E. Beesley and J.T. Lee).
• Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis (Imran Ali and Hassan Y. Aboul-Enein).
• Analytical and Preparative Potential of Immobilized Polysaccharide-derived Chiral Stationary Phases (Tong Zhang and Pilar Franco).
• Chiral Separations Using Supercritical Fluid Chromatography (Karen W. Phinney and Rodger W. Stringham).
• Chiral Separation by Ligand Exchange (Gerald Gübitz and Martin G. Schmid).
• Advances in Simulated Moving Bed Chromatographic Separations (Pedro Sá Gomes, Mirjana Minceva, Luís S. Pais, and Alírio E. Rodrigues).

Introduction

• Modeling Strategies.

Simulation

• Novel SMB Configurations.
• Improvements in Operation Conditions Evaluation (Separation Volume Method).

Conclusions
References

• Less Common Applications of Enantioselective HPLC Using the SMB Technology in the Pharmaceutical Industry (Stefanie Abel and Markus Juza)
• Introduction – From an Emerging Technology to a Classical Unit Operation
• Unbalanced Separations and Multi-component Separations Using SMB
• Unusual Isotherms and Adsorption Behavior
• Applications of Various Column Configurations
• Application of Solvent Gradients
• Chemistry and Racemization
• Future Developments
• Conclusion

Notation

• Greek Letters
• Subscripts
• Acknowledgments
• References
• Enantiomer Separation by Chiral Crown Ether Stationary Phases (Myung Ho Hyun)
• Enantioselective Separation of Amino Acids and Hydroxy Acids by Ligand Exchange with Copper(II) Complexes in HPLC (Chiral Eluent) and in Fast Sensing Systems (Rosangela Marchelli, Roberto Corradini, Gianni Galaverna, Arnaldo Dossena, Francesco Dallavalle, and Stefano Sforza)
• Enantiomer Separation by Capillary Electrophoresis (Gerhard K. E. Scriba)
• Counter-current Chromatography in the Separation of Enantiomers (Eva Pérez and Cristina Minguillón)
• Separation of Enantiomers Using Molecularly Imprinted Polymers (Börje Sellergren)
• Enantioselective Biosensors (Raluca-Ioana Stefan-van Staden, Jacobus Frederick van Staden, and Hassan Y. Aboul-Enein)
• Chiral Analysis in Capillary Electrochromatography (CEC) and CEC Coupled to Mass Spectrometry (Jie Zheng and Shahab A. Shamsi)
• Chiral Analysis Using Polymeric Surfactants in Micellar Electrokinetic Chromatography (MEKC) and MEKC Coupled to Mass Spectrometry (Syed A. A. Rizvi and Shahab A. Shamsi)
• Polarimeter Chiral Detectors in Enantioseparations (Gary W. Yanik)
• Preparative Chiral Chromatography – a Powerful and Efficient Tool in Drug Discovery

This fourth edition of the classic guide for every user of gas chromatographic instrumentation is now updated to include such new topics as fast GC using narrow, short columns, electronic pressure control, and basic aspects of quantitative gas chromatography.

The author shares his many years of experience in technical support for gas chromatography users, addressing the most common problems, questions and misconceptions in capillary gas chromatography. He structures and presents the material in a concise and practical manner, suitable even for the most inexperienced user without any detailed knowledge of chemistry or chromatography.

For lab technicians in chemistry, analytical, food, medicinal and environmental chemists, pharmaceutists.

Table Of Contents :

• Preface

Intentions and Introduction:

• Introduction to Capillary Gas Chromatography
• What Is Gas Chromatography
• What Types of Compounds Are Suitable for GC Analysis
• The Basic Parts of a Gas Chromatograph
• The Chromatogram
• The Mechanism of Compound Separation
• Factors Affecting Separation
• Basic Definitions and Equations
• Capillary GC Columns: Tubing
• Capillary GC Columns: Stationary Phases
• Capillary GC Columns: Dimensions
• Carrier Gas
• Injectors
• Detectors
• Introduction
• Detector Characteristics
• Flame Ionization Detector (FID)
• Nitrogen-Phosphorus Detector (NPD)
• Electron Capture Detector (ECD)
• Thermal Conductivity Detector (TCD)
• Flame Photometric Detector (FPD)
• Mass Spectrometers (MS)
• Column Installation
• Column Test Mixtures
• Causes and Prevention of Column Damage
• Causes of Column Damage and Performance Degradation
• Column Breakage
• Thermal Damage
• Oxygen Damage
• Chemical Damage
• Column Contamination
• Solvent Rinsing Columns
• Guard Columns and Retention Gaps
• Packed Injector Liners
• Gas Impurity Traps
• Column Storage
• Column Repair
• Troubleshooting Guidelines, Approaches and Tests
• Common Capillary GC Problems and Probable Causes
• Using This Troubleshooting Guide
• Troubleshooting Checklist and Pre-Work
• Baseline Problems
• Peak Shape Problems
• Split Peaks
• Negative Peaks
• Excessively Broad Solvent Front
• Loss of Resolution
• Retention Changes
• Peak Size Problems
• Extra or Ghost Peaks (Carryover)
• Rapid Column Deterioration
• Quantitation Problems
• Appendix A Terms
• Appendix B Equations
• Appendix C Mass, Volume and Length Unit Conversions
• Appendix D Column Bleed Mass Spectra
• Appendix E The Basics of High Speed GC Using Small Diameter Columns

Introduction

• Column Considerations.
• Carrier Gas Considerations.
• Injector Considerations.
• Detector and Data System Considerations.
• GC Oven Considerations.
• Sample Considerations.
• An Example of High Speed GC Using a Small Diameter Column.
• High Speed GC Summary.

Appendix F Basic Quantitative Capillary GC:

Intentions:

• De. nitions
• Concentration
• Density (ρ)
• Calibration for Quantitative Purposes
• Quantitation Calculations
• Techniques for Preparation of Analytical Standards for GC

Joachim Ermer (Editor), John H. McB. Miller (Editor) Hardcover418 pages

Adopting a practical approach, the authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book thus allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness.

Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the whole analytical quality assurance system. The whole is rounded off with a look at future trends.

With its first-hand knowledge of the industry as well as regulating bodies, this is an invaluable reference for analytical chemists, the pharmaceutical industry, pharmaceutists, QA officers, and public authorities.

Table of Contents
Preface

List of Contributors:

Part I:

• Fundamentals of Validation in Pharmaceutical Analysis
• Analytical Validation within the Pharmaceutical Environment (Joachim Ermer)
• Performance Parameters, Calculations and Tests
• Case Study: Validation of an HPLC-Method for Identity, Assay, and Related Impurities (Gerd Kleinschmidt)

Part II:

• Life-cycle Approach to Analytical Validation
• Qualification of Analytical Equipment (David Rudd)
• Validation During Drug Product Development – Considerations as a Function of the Stage of Drug Development (Martin Bloch)
• Acceptance Criteria and Analytical Variability (Hermann Watzig)
• Transfer of Analytical Procedures (Mark Broughton and Joachim Ermer (Section 7.3))
• Validation of Pharmacopoeial Methods (John H. McB. Miller)
• Analytical Procedures in a Quality Control Environment (Raymond A. Cox)
• Aberrant or Atypical Results (Christopher Burgess)
• Future Trends in Analytical Method Validation (David Rudd)

Filling a gap in the literature for a hands-on guide focusing on everyday laboratory challenges, this English edition has been expanded and revised using the feedback received on the successful German precursor.

Throughout the book, Professor Mascher draws on his 30 years of experience and provides abundant practical advice, troubleshooting and other hints highlighted in boxes, as well as a broad selection of walk-through case studies. Based on a course taught by the author, the first part of the book intuitively explains all steps of a routine pharmaceutical analysis and explains how to set up a robust, inexpensive and efficient method for a given substance. In the second part he includes 20 worked example cases that highlight common challenges and how to overcome them.
With its appendix containing tried-and-tested analytical methods for 100 clinically relevant substances from the author's own laboratory, complete with spectral and MS data as well as literature references, this is a life-long companion for everyone working in clinical, pharmaceutical and biochemical analysis.


Table of Contents

Preface

Acknowledgements

Introduction:

• First Question: Determination of Ibuprofen in Plasma
• Second Question: Determination of Tryptophan in Urine
• Third Question: Determination of Paclitaxel in Tissue

Planning of Analyses

Introduction:

• Limit of Detection (LOD) and Determination (LLOQ)

Detectors:

• Structure of the Analyte
• Solubility of an Analyte
• Selection of the Detector

Sample Preparation:

• Dilution
• Protein Precipitation, Overview
• Extraction
• HPLC Separation
• HPLC Pumps
• Degasser
• Injector
• HPLC Columns

Detection:

• Detection in the Pharmaceutical/Bioanalytical Area
• Detection in the "Clinical Area" (Therapy Control/Compliance)
• Chemical Derivatization for Detection Enhancement

Validation Concepts:

Introduction:

• Realization of the FDA Guideline
• Practical Hints Concerning Stability, Destruction and Degradation Products
• Metabolites
• Internal Standards
• Case Studies with Intensive Discussion for Each Substance
• Acetylcarnitine in Plasma
• Acetylcysteine in Plasma
• Acyclovir in Plasma and Urine
• Caffeine in Plasma
• Diazepam in Plasma
• Diclofenac in Plasma
• Dihydralazine in Plasma
• Duramycin (Moli1901) in Plasma
• Fluticasone Propionate in Plasma
• Hydroxytriamterene Sulfate and Triameterene in Plasma and Urine
• Ibuprofen in Plasma (also Enantiomeric Separation)
• Minocycline in Plasma
• Norfloxacine in Plasma and Urine
• Paclitaxel in Plasma, Urine and Tissue
• Paracetamol (Acetaminophen) in Plasma
• Pimelic Acid in Plasma and Urine
• Prenylnaringenin in Plasma and Different Types of Tissues
• Silibinin in Plasma
• Valnemulin in Plasma, Different Tissues Types and in Animal Feed
• Vitamin B1 (Total Thiamine) in Plasma
• Table 11.1 Recommended books
• Table 11.2 Properties of Substances

Appendix:

• Short Description of Determination for about 100 Substances
• Substances listed in the Appendix
• A Short Explanation of Tables Presented in the Appendixq

This book coves one of the most important areas in analytical sciences, extraction techniques for organic compounds in environmental and related matrices. This text discusses all of the key stages for analysing a sample for organic compounds from the initial sampling protocols, the range of different Extraction Techniques In Analytical Science for solid, liquid and air samples through to the final chromatographic analysis.

The topics covered include:

• Initial steps for solid, aqueous and air sampling
• Extraction techniques for aqueous samples, including LLE, purge and trap, SPE, SPME, SBSE, SDME, membrane microextraction and MPES
• Extraction techniques for solid samples, including Soxhlet, 'Soxtec', Shake-flask, sonication, PFE, MAE, SFE and MSPD
• Extraction techniques for air sampling, including whole air, enrichment approaches and desorption techniques
• Pre-concentration approaches for post-extraction
• Practical aspects for chromatographic analysis (GC and HPLC) of organic compounds
• Quality assurance aspects of analysis
• Health and safety considerations

Key features include:

• Up-to-date information on the latest development in extraction techniques for organic compounds in environmental and food matrices
• Ideal for use as a self-study guide, as the basis of a taught course or guided reading for new 'early-career' researchers
• Includes a guide for the reader to other sources of information
• Extraction Techniques in Analytical Sciences is suitable for undergraduate and postgraduate students, as well as providing an invaluable starting point for individuals undertaking applied research in the fields of analytical, bioanalytical, environmental and food sciences
• The Analytical Techniques in the Sciences series of books provides coverage of all of the major analytical techniques and their application in the most important areas of physical, life and materials science. Each text is presented in an open learning/distance learning style, in which the learning objectives are clearly identified. the reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions

TABLE OF CONTENTS:

• Series Preface.
• Preface.
• Acknowledgements.
• Acronyms, Abbreviations and Symbols.
• About the Author.
• Pre and Post-Extraction Considerations.

AQUEOUS SAMPLES:

• Classical Approaches for Aqueous Extraction
• Solid Phase Extraction
• Solid Phase Microextraction
• New Developments in Microextraction
• SOLID SAMPLES
• Classical Approaches for Solid-Liquid Extraction
• Pressurized Fluid Extraction
• Microwave-Assisted Extraction
• Matrix Solid Phase Dispersion
• Supercritical Fluid Extraction
• GASEOUS SAMPLES
• Air Sampling
• COMPARISON OF EXTRACTION METHODS
• Comparison of Extraction Methods
• RESOURCES
• Resources for Extraction Techniques
• Responses to Self-Assessment Questions
• Glossary of Terms
• SI Units and Physical Constants
• Periodic Table
• General Index

Since 1884, AOAC INTERNATIONAL has ensured the ability of analytical scientists to have confidence in their results through the adoption of methods as AOAC^®Official Methods^SM. The Official Methods of Analysis of Aoac International is an international source of methods, in which scientists worldwide contribute their expertise to standards development, method development, and the systematic evaluation and review of methods. It is the most comprehensive collection of chemical and microbiological methods available in the world, and many methods within the compendium have notation indicating their adoption as harmonized international reference methods by the International Organization for Standardization (ISO), the International Dairy Federation (IDF), the International Union of Pure and Applied Chemistry (IUPAC), and the Codex Alimentarius Commission.

 

New Material in 20th Edition (2016)

• 59 Methods adopted as First Action
• 22 Methods adopted as Final Action
• 47 Standard Method Performance Requirements (SMPRs®) developed and approved by AOAC stakeholder panels
• 12 Methods with major modification
• 6 Methods repealed
• 1 Appendix (International Stakeholder Panel on Alternative Methods (ISPAM) Guidelines for Validation of Qualitative Binary Chemistry Methods)

 

Additional Information:

• Minimum Order Quantity: 1 Set

Special Indian Reprint !

Reprinted Ed. 2016 ,  February 7, 2008 by CRC Press
Reference - 384 Pages - 70 B/W Illustrations

 

Features

• Provides a concise review of pesticide classes and their physicochemical properties
• Describes specific analytical methods for measuring pesticides in food, soil, water, and air samples
• Highlights effective new technologies for monitoring chemical contaminants
• Addresses regulatory aspects of pesticides in the environment
• Includes extensive reference data on the levels of pesticides found in actual foods and environmental samples

Summary Developing safety regulations for pesticides used around the world—in excess of 2.5 million tons annually—requires reliable analytical methods for assessing their impact in food and in the environment. Analysis of Pesticides in Food and Environmental Samples presents the most effective techniques for analyzing pesticide residues and other chemical contaminants in foods as well as in soil, water, and air.

Renowned Scientists Report New Data and Advances in the Field

The book introduces sample preparation, extraction, and analytical methods specific to each sample type, including foods from vegetal and animal origin. Other chapters discuss important aspects of quality assurance and the applicability of hyphenated analytical techniques. In addition to a practical chapter on the use of biosensors and immunoassays for monitoring and gathering exposure data, the book addresses regulatory aspects and presents current data on the levels of pesticides found in food and environmental matrices.

Latest Methods Help Scientists Develop Safer, More Effective Pesticides

Analysis of Pesticides in Food and Environmental Samples enables scientists to measure and predict the behavior and toxicity of pesticides with a higher degree of accuracy. The methodologies and insight in this timely work will contribute to the development of more effective, less toxic pesticides as well as better safety regulations.

 

Table of Contents Pesticides: Classification and Properties;J.L. Tadeo, C. Sánchez-Brunete, and L.González

Sample Handling of Pesticides in Food and Environmental Samples;E. Turiel and A. Martín-Esteban

Analysis of Pesticides by Chromatographic Techniques Coupled with Mass Spectrometry;S. Hird

Immunoassays and Biosensors;J.M. Van Emon, J.C. Chuang, K. Dill, and G. Xiong

Quality Assurance; Á. Ambrus

Determination of Pesticides in Food of Vegetal Origin;F.J. Schenck and J.W. Wong

Determination of Pesticides in Food of Animal Origin;A.G. Frenich, J.L. Martinez, and A. Covaci

Determination of Pesticides in Soil;C. Sánchez-Brunete, B. Albero, and J.L. Tadeo

Determination of Pesticides in Water; J. Gan and S. Bondarenko

Sampling and Analysis of Pesticides in the Atmosphere;M. Millet

Levels of Pesticides in Food and Food Safety Aspects;K. Granby, A. Petersen, S.S. Herrmann, and M.E. Poulsen

Monitoring of Pesticides in the Environment;I. Konstantinou, D. Hela, D. Lambropoulou, and T. Albanis

Index 
*Each Chapter contains a full Introduction and References

Additional Information:

• Minimum Order Quantity: 1 Piece

The official methods of analysis SM, 19th edition (print), is now available for purchase. the print edition is a 2-volume set (hard cover bound books; not a subscription). following are highlights in the new edition: 31 methods adopted as first action 16 smprs developed and approved by aoac stakeholder panels 7 methods with major modifications 10 methods with minor editorial revisions 7 new appendices on guidelines for smprs, voluntary consensus standards, probability of detection, validation of microbiological methods for foods and environmental surfaces, validation of dietary supplements and botanical, single-laboratory validation of infant formula and adult nutritionals, and validation of food allergens a new subchapter on general screening methods (chapter 17, subchapter 15) that includes screening methods for bacteria updated information on program components of the official method process (found in the front matter)

Feature:

• Hard cover bound books
• One can search the book under the following keywords: AOAC ANALYSIS , Official Methods of Analysis , AOAC Official Methods , FDA Guidelines, AOAC Official Methods of Analysis , AOAC Methods , AOAC

Published:October 12, 2009 by CRC Press - 2850 Pages Editor(s):Jack Cazes, Consultant, Lady Lake, Florida, USA

Features:

• Includes essential information for novice and experienced scientists
• Contains two tables of contents: one in alphabetical order and the other by category of chromatography
• Provides concise definitions of terms
• Explores scientific methods, background, optimization, practice, and theory
• Updates most articles and adds many new entries

Summary:

• Thoroughly revised and expanded, the third edition of the Encyclopedia of Chromatography is an authoritative source of information for researchers in chemistry, biology, physics, engineering, and materials science. This quick reference and guide to specific chromatographic techniques and theory provides a basic introduction to the science and technology of the method, offering key references dealing with the methodology for analysis of specific chemicals and applications in industry. With a focus on emerging technologies and uses, the text contains tables and figures that cogently illustrate and clarify technical points in the articles. The Third Edition provides a valuable, reader-friendly reference for all those who employ chromatographic methods for analysis of complex mixtures of substances, as well as practitioners across the entire spectrum of science
• What’s New in the Third Edition
• Bioanalysis: Silica- and Polymer-Based Monolithic Columns
• Bioluminescence: Detection in TLC
• Chemical Warfare Agent Degradation Products: HPLC/MS Analysis
• Chemical Warfare Agents: TLC Analysis
• Cyclodextrins in GC
• Cyclodextrins in HPLC
• Detection in Ion Chromatography
• Drug Development: LC/MS
• Flash Chromatography
• Food Analysis: Ion Chromatography
• Inorganic and Organic Cations: Ion Chromatographic Determination
• Inverse GC
• Multidimensional Separations
• Spiral Column Assembly for HSCCC
• Thin Layer Radiochromatography
• Topological Indices: TLC
• UV-Visible Detection Including Multiple Wavelengths

TABLE OF CONTENTS:

• Affinity Chromatography
• Amino Acids / Peptides / Proteins
• Basic Theory / Definitions
• Biomedical
• CCC (Countercurrent Chromatography)
• CE / CEC, and Related Techniques
• Chiral Techniques
• Derivatization
• Detection / Detectors
• FFF (Field-Flow Fractionation)
• GC (Gas Chromatography)
• Gradient / Programmed Techniques
• HPLC
• Multidimensional Techniques
• Natural Products
• Pharmaceuticals
• Polymers and Additives
• Preparative Chromatography
• Sampling Techniques
• SEC / GPC (Size Exclusion / Gel Permeation)
• SFC / SFE (Supercritical Fluid Techniques)
• Solvents / Mobile Phases
• Stationary Phases, Columns
• TLC (Thin Layer Chromatography)

The official methods of analysis SM, 19th edition (print), is now available for purchase. the print edition is a 2-volume set (hard cover bound books; not a subscription). following are highlights in the new edition: 31 methods adopted as first action 16 smprs developed and approved by aoac stakeholder panels 7 methods with major modifications 10 methods with minor editorial revisions 7 new appendices on guidelines for smprs, voluntary consensus standards, probability of detection, validation of microbiological methods for foods and environmental surfaces, validation of dietary supplements and botanicals, single-laboratory validation of infant formula and adult nutritionals, and validation of food allergens a new subchapter on general screening methods (chapter 17, subchapter 15) that includes screening methods for bacteria updated information on program components of the official methodssm process (found in the front matter)


Print:

• The print edition is a 2-volume set, hard cover bound books (not a subscription)
• Following are highlights in the new edition:
• Methods adopted as First Action
• Standard Method Performance Requrements (SMPRs) developed and approved by AOAC stakeholder panels
• Methods with major modifications
• Methods with minor editorial revisions
• New appendices on guidelines for SMPRs, voluntary consensus standards, probability of detection, validation of microbiological methods for foods and environmental surfaces, validation of dietary supplements and botanicals, single-laboratory validation of infant formula and adult nutritionals, and validation of food allergens
• A new subchapter on General Screening Methods (Chapter 17, subchapter 15) that includes screening methods for bacteria
• Updated information on program components of the Official MethodsSM process (found in the front matter)